POS-375 AVACOPAN IN ANCA-ASSOCIATED VASCULITIS: EVIDENCE FOR ELIMINATION OF DAILY PREDNISONE THERAPY AND REDUCTION IN GLUCOCORTICOID-RELATED TOXICITY FROM THE PHASE 3 ADVOCATE TRIAL

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a life- or organ-threatening condition with systemic anti-neutrophil autoantibodies and small vessel inflammation. Therapy with high-dose glucocorticoids (GCs) improves the symptoms of acute vasculitis, but significant therapy-induced toxicities and comorbidities...