Consistent skin α-synuclein positivity in REM sleep behavior disorder – A two center two-to-four-year follow-up study

Volume: 86, Pages: 108 - 113
Published: May 1, 2021
Abstract
Phosphorylated alpha-synuclein (p-syn) in dermal nerves of patients with isolated REM sleep behavior disorder (iRBD) is detectable by immunofluorescence-labeling. Skin-biopsy-p-syn-positivity was recently postulated to be a prodromal marker of Parkinson's disease (PD) or related synucleinopathies. Here, we provide two-to four-year clinical and skin biopsy follow-up data of 33 iRBD patients, whose skin biopsy findings at baseline were reported in...
Paper Details
Title
Consistent skin α-synuclein positivity in REM sleep behavior disorder – A two center two-to-four-year follow-up study
Published Date
May 1, 2021
Volume
86
Pages
108 - 113
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