Metabolic Activation and Cytotoxicity of Labetalol Hydrochloride Mediated by Sulfotransferases
Abstract
Labetalol hydrochloride (LHCl), an α- and β-adrenoreceptor blocker, is widely used for the treatment of hypertension as well as angina pectoris. Previous reports have demonstrated the adverse events during clinical application of LHCl, such as liver injury and acute renal failure. The present study aimed to investigate metabolic activation of LHCl to initiate the elucidation of the mechanisms of its liver toxicity. One glutathione (GSH)...
Paper Details
Title
Metabolic Activation and Cytotoxicity of Labetalol Hydrochloride Mediated by Sulfotransferases
Published Date
Apr 19, 2021
Volume
34
Issue
6
Pages
1612 - 1618
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