622 TNFα in impaired diabetic wound healing: A role for GM3

Type 2 diabetes (T2D) is associated with chronic exposure to increases in tumor necrosis factor alpha (TNFα), which contributes to insulin resistance and the development of foot ulcers in 25% of affected individuals. The mechanism by which TNFα leads to insulin resistance and poor wound healing is unclear. We hypothesized that glycosphingolipid GM3 is a critical mediator of TNFα-induced pathology in diabetic skin. In undifferentiated, cultured...