Identification of a novel regulator of adamts-5-mediated aggrecan degradation in chondrocytes

Purpose: There are currently no therapies to reduce cartilage loss in osteoarthritis. Our group has been studying the molecular mechanisms regulating the activity of proteases involved in osteoarthritis pathogenesis to identify new therapeutic targets. To do this, we have focused on proteins required for formation and function of an organelle called the primary cilium. We have previously seen that a hypomorphic mutation affecting the ciliary...