Combining species specific in vitro & in silico models to predict in vivo food effect in a preclinical stage – case study of Venetoclax

Volume: 162, Pages: 105840 - 105840
Published: Jul 1, 2021
Abstract
The pig has been increasingly used as a reliable preclinical model for assessing and predicting the in vivo bioavailability of different formulation strategies. Nevertheless, differences in the composition between porcine and human intestinal fluids, may impact on the solubility and dissolution behaviour of drugs, in particular BCS II/IV drugs. Recently, a porcine fasted simulated intestinal fluid (FaSSIFp) was developed to mimic the composition...
Paper Details
Title
Combining species specific in vitro & in silico models to predict in vivo food effect in a preclinical stage – case study of Venetoclax
Published Date
Jul 1, 2021
Volume
162
Pages
105840 - 105840
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