Biomarker-Based Risk Prediction With the ABC-AF Scores in Patients With Atrial Fibrillation Not Receiving Oral Anticoagulation.

Published on May 11, 2021in Circulation23.603
· DOI :10.1161/CIRCULATIONAHA.120.053100
Alexander P. Benz3
Estimated H-index: 3
(Population Health Research Institute),
Ziad Hijazi25
Estimated H-index: 25
(Uppsala University)
+ 5 AuthorsLars Wallentin150
Estimated H-index: 150
(Uppsala University)
Sources
Abstract
Background: The novel ABC (Age, Biomarkers, Clinical History) scores outperform traditional risk scores for stroke, major bleeding and death in patients with atrial fibrillation (AF) receiving oral...
References28
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#1Gerhard HindricksH-Index: 90
#2Tatjana S. PotparaH-Index: 37
Last. Caroline L WatkinsH-Index: 35
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759 CitationsSource
#1Peter C. Austin (U of T: University of Toronto)H-Index: 124
#2Frank E. Harrell (Vandy: Vanderbilt University)H-Index: 112
Last. David van Klaveren (EUR: Erasmus University Rotterdam)H-Index: 24
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In the context of survival analysis, calibration refers to the agreement between predicted probabilities and observed event rates or frequencies of the outcome within a given duration of time. We aimed to describe and evaluate methods for graphically assessing the calibration of survival models. We focus on hazard regression models and restricted cubic splines in conjunction with a Cox proportional hazards model. We also describe modifications of the Integrated Calibration Index, of E50 and of E...
7 CitationsSource
#1Craig T. JanuaryH-Index: 53
#1Craig T. JanuaryH-Index: 15
Last. Clyde W. YancyH-Index: 121
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683 CitationsSource
#1David D. Berg (Brigham and Women's Hospital)H-Index: 16
#2Christian T. Ruff (Brigham and Women's Hospital)H-Index: 46
Last. David A. Morrow (Brigham and Women's Hospital)H-Index: 126
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Background: The ABC (age, biomarker, clinical history)-stroke and ABC-bleeding risk scores incorporate clinical variables and cardiovascular biomarkers to estimate risk of stroke or systemic emboli...
47 CitationsSource
#1Abhinav Sharma (Duke University)H-Index: 23
#2Ziad Hijazi (Uppsala University)H-Index: 25
Last. Lars Wallentin (Uppsala University)H-Index: 150
view all 14 authors...
Background —Atrial fibrillation (AF) is associated with an increased risk of death. High-sensitivity troponin-T, growth differentiation factor-15 (GDF-15), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and interleukin-6 levels are predictive of cardiovascular (CV) events and total and CV death in anticoagulated AF patients. The prognostic utility of these biomarkers for cause-specific death is unknown. Methods —The ARISTOTLE trial randomized 18,201 patients with AF to apixaban or warfar...
19 CitationsSource
#1Ziad Hijazi (Uppsala University)H-Index: 25
#2Jonas Oldgren (Uppsala University)H-Index: 51
Last. Lars Wallentin (Uppsala University)H-Index: 150
view all 14 authors...
Aims: In atrial fibrillation (AF), mortality remains high despite effective anticoagulation. A model predicting the risk of death in these patients is currently not available. We developed and vali ...
53 CitationsSource
#1Jonas Oldgren (Uppsala University)H-Index: 51
#2Ziad Hijazi (Uppsala University)H-Index: 25
Last. Lars Wallentin (Uppsala University)H-Index: 150
view all 13 authors...
Background:Atrial fibrillation is associated with increased but variable risk of stroke. Our aim was to validate the recently developed biomarker-based ABC (age, biomarkers [high-sensitivity tropon...
59 CitationsSource
#1P KirchhofH-Index: 4
#1Paulus KirchhofH-Index: 108
Last. P.E. VardasH-Index: 27
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The Task Force for the management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC Endorsed by the European Stroke Organisation (ESO)
3,837 CitationsSource
#1Ziad Hijazi (Uppsala University)H-Index: 25
#2Jonas Oldgren (Uppsala University)H-Index: 51
Last. Lars Wallentin (Uppsala University)H-Index: 150
view all 14 authors...
Summary Background The benefit of oral anticoagulation in atrial fibrillation is based on a balance between reduction in ischaemic stroke and increase in major bleeding. We aimed to develop and validate a new biomarker-based risk score to improve the prognostication of major bleeding in patients with atrial fibrillation. Methods We developed and internally validated a new biomarker-based risk score for major bleeding in 14 537 patients with atrial fibrillation randomised to apixaban versus warfa...
245 CitationsSource
#1Ziad Hijazi (Uppsala University)H-Index: 25
#2Johan Lindbäck (Uppsala University)H-Index: 43
Last. Lars Wallentin (Uppsala University)H-Index: 150
view all 13 authors...
Aims Atrial fibrillation (AF) is associated with an increased risk of stroke, which is currently estimated by clinical characteristics. The cardiac biomarkers N-terminal fragment B-type natriuretic peptide (NT-proBNP) and cardiac troponin high-sensitivity (cTn-hs) are independently associated with risk of stroke in AF. Our objective was to develop and validate a new biomarker-based risk score to improve prognostication of stroke in patients with AF. Methods and results A new risk score was devel...
221 CitationsSource
Cited By1
Newest
#1Alexander P. Benz (Population Health Research Institute)H-Index: 3
#2John W. Eikelboom (Population Health Research Institute)H-Index: 121
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