Effects of Zoledronic Acid on Human Gingival Fibroblasts and Human Umbilical Vein Endothelial Cells

We evaluated the effects of zoledronic acid (ZOL) on human gingival fibroblasts (HGFs) and human umbilical vein endothelial cells (HUVECs) associated with wound healing in oral soft tissues. HGFs and HUVECs were divided into two groups: a culture media control group and a group exposed to ZOL (50 μM). Cell proliferation was measured after 2, 4, 6, and 8 days. The migration ability of cells was measured for each experiment using the wound healing...