Design, synthesis of novel celastrol derivatives and study on their antitumor growth through HIF-1α pathway
Abstract
Four series of hypoxia-inducible factor-1 alpha (HIF-1α) functioning derivatives stemming from modifications to the C-29 carboxyl group of celastrol were designed and synthesized, and their anticancer activities were evaluated. To address the structure and activity relationship of each derivative, extensive structural changes were made. HRE luciferase reporter assay demonstrated that 12 modified compounds showed superior HIF-1α inhibitory...
Paper Details
Title
Design, synthesis of novel celastrol derivatives and study on their antitumor growth through HIF-1α pathway
Published Date
Aug 1, 2021
Volume
220
Pages
113474 - 113474
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