STAT5

FOXP3

Autoimmunity

IL-2 receptor

Transcription factor

Biology

Gene

Enhancer

Immunology

T cell

Immune tolerance

Regulatory T cell

Signal transduction

Cell biology

Cancer research

Genetics

Immune system

Immunity

IL-2 coordinates with other environmental cues to induce Foxp3 expression during Treg cell development, a critical step in establishing immune tolerance. In this issue of Immunity, Dikiy et al. identify an enhancer responsible for IL-2 dependent Foxp3 induction and reveal its important role in buffering autoimmune pathology.

A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance