Targeting Ovarian Cancer Stem Cells by Dual Inhibition of HOTAIR and DNA Methylation
Abstract
Ovarian cancer is a chemoresponsive tumor with very high initial response rates to standard therapy consisting of platinum/paclitaxel. However, most women eventually develop recurrence, which rapidly evolves into chemoresistant disease. Persistence of ovarian cancer stem cells (OCSCs) at the end of therapy has been shown to contribute to resistant tumors. In this study, we demonstrate that the long noncoding RNA HOTAIR is overexpressed in HGSOC...
Paper Details
Title
Targeting Ovarian Cancer Stem Cells by Dual Inhibition of HOTAIR and DNA Methylation
Published Date
Mar 30, 2021
Volume
20
Issue
6
Pages
1092 - 1101
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