Enzyme-Agnostic Lysosomal Screen Identifies New Legumain-Cleavable ADC Linkers
Abstract
Over the past two decades, antibody drug conjugates (ADCs) and small molecule drug conjugates (SMDCs) have widely employed valine-citruline and related cathepsin-cleavable linkers due to their stability in plasma and their rapid cleavage by lysosomal cathepsins. However, a number of recent studies have illustrated that these linkers are subject to cleavage by exogenous enzymes such as Ces1C and neutrophil elastase, thus resulting in off-target...
Paper Details
Title
Enzyme-Agnostic Lysosomal Screen Identifies New Legumain-Cleavable ADC Linkers
Published Date
Mar 31, 2021
Journal
Volume
32
Issue
4
Pages
842 - 858
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