Dual roles of SAMHD1 in tumor development and chemoresistance to anticancer drugs (Review)

Volume: 21, Issue: 6
Published: Apr 8, 2021
Abstract
Human sterile alpha motif and HD‑domain‑­containing protein 1 (SAMHD1) has been identified as a GTP or dGTP‑dependent deoxynucleotide triphosphohydrolase (dNTPase) and acts as an antiviral factor against certain retroviruses and DNA viruses. Genetic mutation in SAMHD1 causes the inflammatory Aicardi‑Goutières Syndrome and abnormal intracellular deoxyribonucleoside triphosphates (dNTPs) pool. At present, the role of SAMHD1 in numerous types of...
Paper Details
Title
Dual roles of SAMHD1 in tumor development and chemoresistance to anticancer drugs (Review)
Published Date
Apr 8, 2021
Volume
21
Issue
6
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