Thymosin β4 protects against aortic aneurysm via endocytic regulation of growth factor signaling
Abstract
Vascular stability and tone are maintained by contractile smooth muscle cells (VSMCs). However, injury-induced growth factors stimulate a contractile-synthetic phenotypic modulation which increases susceptibility to abdominal aortic aneurysm (AAA). As a regulator of embryonic VSMC differentiation, we hypothesized that Thymosin β4 (Tβ4) may function to maintain healthy vasculature throughout postnatal life. This was supported by the...
Paper Details
Title
Thymosin β4 protects against aortic aneurysm via endocytic regulation of growth factor signaling
Published Date
May 17, 2021
Volume
131
Issue
10
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