Prognostic and therapeutic implications of extracellular matrix associated gene signature in renal clear cell carcinoma

Complex interactions in tumor microenvironment between ECM (extra-cellular matrix) and cancer cell plays a central role in the generation of tumor supportive microenvironment. In this study, the expression of ECM-related genes was explored for prognostic and immunological implication in clear cell renal clear cell carcinoma (ccRCC). Out of 964 ECM genes, higher expression ( z -score > 2) of 35 genes showed significant association with overall...