26 Lessons learned from complement inhibition in ANCA vasculitis

In the absence of cures for multi-system inflammatory disease, therapies aim to dampen long-term inflammation, control symptoms and prevent tissue damage. Glucocorticoids (GC) are a key anti-inflammatory agent with a rapid mode of action and broad targeting of multiple pathways. However, GC toxicity causes organ damage affecting organ function and patient quality of life.¹ Recent advances in anti-neutrophil cytoplasmic...