Pressure overload

Transplantation

GATA4

Cancer research

Biology

Gene

Endocrinology

Kinase

MAPK/ERK pathway

Cell biology

Muscle hypertrophy

NFAT

Signal transduction

Calcineurin

Cardiac hypertrophy

Internal medicine

Transcription factor

Genetics

Medicine

Circulation

Cardiac hypertrophy is an independent risk factor for heart failure, a leading cause of morbidity and mortality globally. The calcineurin/NFAT (nuclear factor of activated T cells) pathway and the MAPK (mitogen-activated protein kinase)/Erk (extracellular signal-regulated kinase) pathway contribute to the pathogenesis of cardiac hypertrophy as an interdependent network of signaling cascades. How these pathways interact remains unclear and few direct targets responsible for the prohypertrophic role of NFAT have been described.

Cooperative Binding of ETS2 and NFAT Links Erk1/2 and Calcineurin Signaling in the Pathogenesis of Cardiac Hypertrophy