Kynurenine emerges from the shadows – Current knowledge on its fate and function

Volume: 225, Pages: 107845 - 107845
Published: Sep 1, 2021
Abstract
Kynurenine (KYN), a main metabolite of tryptophan in mammals, is a direct precursor of kynurenic acid, anthranilic acid and 3-hydroxykynurenine (3-HK). Under physiological conditions, KYN is produced endogenously mainly in the liver by tryptophan 2,3-dioxygenase (TDO). Tumorigenesis and inflammatory conditions increase the activity of another KYN synthetizing enzyme, indoleamine 2,3-dioxygenase (IDO). However, knowledge about the exogenous...
Paper Details
Title
Kynurenine emerges from the shadows – Current knowledge on its fate and function
Published Date
Sep 1, 2021
Volume
225
Pages
107845 - 107845
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