Chromatin Regulator SPEN/SHARP in X Inactivation and Disease
Abstract
Enzymes, such as histone methyltransferases and demethylases, histone acetyltransferases and deacetylases, and DNA methyltransferases are known as epigenetic modifiers that are often implicated in tumorigenesis and disease. One of the best-studied chromatin-based mechanism is X chromosome inactivation (XCI), a process that establishes facultative heterochromatin on only one X chromosome in females and establishes the right dosage of gene...
Paper Details
Title
Chromatin Regulator SPEN/SHARP in X Inactivation and Disease
Published Date
Apr 1, 2021
Journal
Volume
13
Issue
7
Pages
1665 - 1665
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Notes
History