Amylin Analog Pramlintide Induces Migraine‐like Attacks in Patients

Migraine is a prevalent and disabling neurological disease. Its genesis is poorly understood, and there remains unmet clinical need. We aimed to identify mechanisms and thus novel therapeutic targets for migraine using human models of migraine and translational models in animals, with emphasis on amylin, a close relative of calcitonin gene-related peptide (CGRP).Thirty-six migraine without aura patients were enrolled in a randomized,...