Development of a method for generating SNP interaction-aware polygenic risk scores for radiotherapy toxicity

Volume: 159, Pages: 241 - 248
Published: Jun 1, 2021
Abstract
To identify the effect of single nucleotide polymorphism (SNP) interactions on the risk of toxicity following radiotherapy (RT) for prostate cancer (PCa) and propose a new method for polygenic risk score incorporating SNP-SNP interactions (PRSi).Analysis included the REQUITE PCa cohort that received external beam RT and was followed for 2 years. Late toxicity endpoints were: rectal bleeding, urinary frequency, haematuria, nocturia, decreased...
Paper Details
Title
Development of a method for generating SNP interaction-aware polygenic risk scores for radiotherapy toxicity
Published Date
Jun 1, 2021
Volume
159
Pages
241 - 248
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