Matrix compliance permits NF-κB activation to drive therapy resistance in breast cancer
Abstract
Triple-negative breast cancers (TNBCs) are associated with poor survival mediated by treatment resistance. TNBCs are fibrotic, yet little is known regarding how the extracellular matrix (ECM) evolves following therapy and whether it impacts treatment response. Analysis revealed that while primary untreated TNBCs are surrounded by a rigid stromal microenvironment, chemotherapy-resistant residual tumors inhabit a softer niche. TNBC organoid...
Paper Details
Title
Matrix compliance permits NF-κB activation to drive therapy resistance in breast cancer
Published Date
Apr 2, 2021
Volume
218
Issue
5
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