H2AK119ub1 guides maternal inheritance and zygotic deposition of H3K27me3 in mouse embryos
Abstract
Parental epigenomes are established during gametogenesis. While they are largely reset after fertilization, broad domains of Polycomb repressive complex 2 (PRC2)-mediated formation of lysine 27-trimethylated histone H3 (H3K27me3) are inherited from oocytes in mice. How maternal H3K27me3 is established and inherited by embryos remains elusive. Here, we show that PRC1-mediated formation of lysine 119-monoubiquititinated histone H2A (H2AK119ub1)...
Paper Details
Title
H2AK119ub1 guides maternal inheritance and zygotic deposition of H3K27me3 in mouse embryos
Published Date
Apr 1, 2021
Journal
Volume
53
Issue
4
Pages
539 - 550
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