Internal medicine

Biliary tract

FOLFOX

Oxaliplatin

Open label

Colorectal cancer

Cancer

Oncology

Randomized controlled trial

Chemotherapy

Biliary tract cancer

Gemcitabine

Medicine

The Lancet Oncology

Advanced biliary tract cancer has a poor prognosis. Cisplatin and gemcitabine is the standard first-line chemotherapy regimen, but no robust evidence is available for second-line chemotherapy. The aim of this study was to determine the benefit derived from second-line FOLFOX (folinic acid, fluorouracil, and oxaliplatin) chemotherapy in advanced biliary tract cancer.

Second-line FOLFOX chemotherapy versus active symptom control for advanced biliary tract cancer (ABC-06): a phase 3, open-label, randomised, controlled trial