Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels
Abstract
Cancer recurrence can arise owing to rare circulating cancer stem cells (CSCs) that are resistant to chemotherapies and radiotherapies. Here, we show that a double-network hydrogel can rapidly reprogramme differentiated cancer cells into CSCs. Spheroids expressing elevated levels of the stemness genes Sox2, Oct3/4 and Nanog formed within 24 h of seeding the gel with cells from any of six human cancer cell lines or with brain cancer cells...
Paper Details
Title
Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels
Published Date
Mar 29, 2021
Volume
5
Issue
8
Pages
914 - 925
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