Green Synthesis of Silver Nanoparticles Using Extract of Cilembu Sweet Potatoes (Ipomoea batatas L var. Rancing) as Potential Filler for 3D Printed Electroactive and Anti-Infection Scaffolds

Published on Apr 2, 2021in Molecules3.267
· DOI :10.3390/MOLECULES26072042
Arie Wibowo5
Estimated H-index: 5
,
Gusti Umindya Nur Tajalla1
Estimated H-index: 1
+ 5 AuthorsPaulo Jorge Da Silva Bartolo45
Estimated H-index: 45
Source
Abstract
Electroactive biomaterials are fascinating for tissue engineering applications because of their ability to deliver electrical stimulation directly to cells, tissue, and organs. One particularly attractive conductive filler for electroactive biomaterials is silver nanoparticles (AgNPs) because of their high conductivity, antibacterial activity, and ability to promote bone healing. However, production of AgNPs involves a toxic reducing agent which would inhibit biological scaffold performance. This work explores facile and green synthesis of AgNPs using extract of Cilembu sweet potato and studies the effect of baking and precursor concentrations (1, 10 and 100 mM) on AgNPs' properties. Transmission electron microscope (TEM) results revealed that the smallest particle size of AgNPs (9.95 ± 3.69 nm) with nodular morphology was obtained by utilization of baked extract and ten mM AgNO3. Polycaprolactone (PCL)/AgNPs scaffolds exhibited several enhancements compared to PCL scaffolds. Compressive strength was six times greater (3.88 ± 0.42 MPa), more hydrophilic (contact angle of 76.8 ± 1.7°), conductive (2.3 ± 0.5 × 10-3 S/cm) and exhibited anti-bacterial properties against Staphylococcus aureus ATCC3658 (99.5% reduction of surviving bacteria). Despite the promising results, further investigation on biological assessment is required to obtain comprehensive study of this scaffold. This green synthesis approach together with the use of 3D printing opens a new route to manufacture AgNPs-based electroactive with improved anti-bacterial properties without utilization of any toxic organic solvents.
Download
References74
Newest
#1Andrea Rónavári (University of Szeged)H-Index: 9
#2Nóra Igaz (University of Szeged)H-Index: 8
Last. Mónika Kiricsi (University of Szeged)H-Index: 13
view all 8 authors...
The nanomaterial industry generates gigantic quantities of metal-based nanomaterials for various technological and biomedical applications; however, concomitantly, it places a massive burden on the environment by utilizing toxic chemicals for the production process and leaving hazardous waste materials behind. Moreover, the employed, often unpleasant chemicals can affect the biocompatibility of the generated particles and severely restrict their application possibilities. On these grounds, green...
7 CitationsSource
#1Sina KaabipourH-Index: 2
#2Shohreh Hemmati (OSU: Oklahoma State University–Stillwater)H-Index: 5
Last. Shohreh HemmatiH-Index: 1
view all 2 authors...
The significance of silver nanostructures has been growing considerably, thanks to their ubiquitous presence in numerous applications, including but not limited to renewable energy, electronics, biosensors, wastewater treatment, medicine, and clinical equipment. The properties of silver nanostructures, such as size, size distribution, and morphology, are strongly dependent on synthesis process conditions such as the process type, equipment type, reagent type, precursor concentration, temperature...
6 CitationsSource
#2Preethi VincentH-Index: 2
Last. Sekaran SaravananH-Index: 31
view all 8 authors...
Abstract Scaffolds fabricated with only chitosan (CS) as base polymer is limited by its fast degradation rate, reduced mechanical strength and diminished bioactivity. To achieve optimal properties suitable for bone tissue engineering, CS based scaffolds are developed by addition of copolymers, nanoparticles, and functional group modifications. In our study, biodegradable composite scaffolds were fabricated by utilizing CS and silver nanoparticles (AgNPs) were in-situ synthesised on CS matrix wit...
7 CitationsSource
#1Socrates Radhakrishnan (Anna University)H-Index: 3
#2Sakthivel Nagarajan (CNRS: Centre national de la recherche scientifique)H-Index: 9
Last. Mikhael Bechelany (CNRS: Centre national de la recherche scientifique)H-Index: 55
view all 17 authors...
ABSTRACT Synthetic polymers are widely employed for bone tissue engineering due to their tunable physical properties and biocompatibility. Inherently, most of these polymers display poor antimicrobial properties. Infection at the site of implantation is a major cause for failure or delay in bone healing process and the development of antimicrobial polymers is highly desired. In this study, silver nanoparticles (AgNps) were synthesized in polycaprolactone (PCL) solution by in-situ reduction and f...
10 CitationsSource
#1Weiguang WangH-Index: 48
#2Yanhao HouH-Index: 2
view all 6 authors...
The use of electrically conductive materials to impart electrical properties to substrates for cell attachment proliferation and differentiation represents an important strategy in the field of tissue engineering. This paper discusses the concept of electro-active structures and their roles in tissue engineering, accelerating cell proliferation and differentiation, consequently leading to tissue regeneration. The most relevant carbon-based materials used to produce electro-active structures are ...
4 CitationsSource
#1S. M. Abu NayemH-Index: 2
#2Nasrin Sultana (Jagannath University)H-Index: 2
Last. A. J. Saleh AhammadH-Index: 19
view all 11 authors...
In this report, we discussed rapid, facile one-pot green synthesis of gold and silver nanoparticles (AuNPs and AgNPs) by using tuber extract of Amorphophallus paeoniifolius, and evaluated their antibacterial activity. AuNPs and AgNPs were synthesized by mixing their respective precursors (AgNO3 and HAuCl4) with tuber extract of Amorphophallus paeoniifolius as the bio-reducing agent. Characterization of AuNPs and AgNPs were confirmed by applying UV-vis spectroscopy, field-emission scanning electr...
4 CitationsSource
#1Li XuH-Index: 1
#2Yi Yi Wang (CSU: Central South University)H-Index: 1
Last. Xie Hui
view all 6 authors...
Silver nanoparticles (AgNPs) have been one of the most attractive nanomaterials in biomedicine due to their unique physicochemical properties. In this paper, we review the state-of-the-art advances of AgNPs in the synthesis methods, medical applications and biosafety of AgNPs. The synthesis methods of AgNPs include physical, chemical and biological routes. AgNPs are mainly used for antimicrobial and anticancer therapy, and also applied in the promotion of wound repair and bone healing, or as the...
47 CitationsSource
#1Pavel L. Padnya (Kazan: Kazan Federal University)H-Index: 11
#2Vladimir V. Gorbachuk (Kazan: Kazan Federal University)H-Index: 9
Last. Ivan I. Stoikov (Kazan: Kazan Federal University)H-Index: 23
view all 3 authors...
Silver nanoparticles (AgNPs) are an attractive alternative to plasmonic gold nanoparticles. The relative cheapness and redox stability determine the growing interest of researchers in obtaining selective plasmonic and electrochemical (bio)sensors based on silver nanoparticles. The controlled synthesis of metal nanoparticles of a defined morphology is a nontrivial task, important for such fields as biochemistry, catalysis, biosensors and microelectronics. Cyclophanes are well known for their grea...
15 CitationsSource
#1Arie Wibowo (ITB: Bandung Institute of Technology)H-Index: 5
#2Cian Vyas (University of Manchester)H-Index: 10
Last. Paulo Jorge Da Silva Bartolo (University of Manchester)H-Index: 45
view all 8 authors...
Electrostimulation and electroactive scaffolds can positively influence and guide cellular behaviour and thus has been garnering interest as a key tissue engineering strategy. The development of conducting polymers such as polyaniline enables the fabrication of conductive polymeric composite scaffolds. In this study, we report on the initial development of a polycaprolactone scaffold incorporating different weight loadings of a polyaniline microparticle filler. The scaffolds are fabricated using...
25 CitationsSource
#1Kseniya Hileuskaya (NASB: National Academy of Sciences of Belarus)H-Index: 5
#2Alena Ivanovna Ladutska (NASB: National Academy of Sciences of Belarus)H-Index: 1
Last. Vladimir Agabekov (NASB: National Academy of Sciences of Belarus)H-Index: 14
view all 8 authors...
Abstract The development of environmentally friendly, non-toxic and cheap technology for synthesis of silver nanoparticles with desired properties is currently under intensive investigation because such materials show huge potential for numerous biomedical applications. In this paper, we propose the ‘green’ technique to obtain stable silver nanoparticles using reducing and stabilizing capacity of natural polysaccharide pectin. The relationship between physico-chemical characteristics of formed p...
28 CitationsSource
Cited By1
Newest
Last. Ahmed Barhoum (Helwan University)H-Index: 22
view all 7 authors...
In this study, silver/silver oxide nanoparticles (Ag/Ag2O NPs) were successfully biosynthesized using Phoenix dactylifera L. aqueous leaves extract. The effect of different plant extract/precursor contractions (volume ratio, v/v%) on Ag/Ag2O NP formation, their optical properties, and photocatalytic activity towards azo dye degradation, i.e., Congo red (CR) and methylene blue (MB), were investigated. X-ray diffraction confirmed the crystalline nature of Ag/Ag2O NPs with a crystallite size range ...
Source