Development and characterization of a novel flavopiridol formulation for treatment of acute myeloid leukemia
Abstract
For more than 30 years, treatment of acute myeloid leukemia (AML) has remained largely unchanged and reliant on chemotherapeutic drug combinations, specifically cytarabine and daunorubicin (the 7 + 3 regimen). One broad spectrum drug, flavopiridol (also known as Alvocidib) has shown significant activity against AML through the inhibition of cyclin-dependent kinases. Flavopiridol is a semisynthetic flavonoid and our research team recently...
Paper Details
Title
Development and characterization of a novel flavopiridol formulation for treatment of acute myeloid leukemia
Published Date
May 1, 2021
Volume
333
Pages
246 - 257
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