The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA
Abstract
The SARS-CoV-2 nucleocapsid (N) protein is an abundant RNA-binding protein critical for viral genome packaging, yet the molecular details that underlie this process are poorly understood. Here we combine single-molecule spectroscopy with all-atom simulations to uncover the molecular details that contribute to N protein function. N protein contains three dynamic disordered regions that house putative transiently-helical binding motifs. The two...
Paper Details
Title
The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA
Published Date
Mar 29, 2021
Journal
Volume
12
Issue
1
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