Recent advances in research of colchicine binding site inhibitors and their interaction modes with tubulin
Abstract
Microtubules have been a concerning target of cancer chemotherapeutics for decades, and several tubulin-targeted agents, such as paclitaxel, vincristine and vinorelbine, have been approved. The colchicine binding site is one of the primary targets on microtubules and possesses advantages compared with other tubulin-targeted agents, such as inhibitors of tumor vessels and overcoming P-glycoprotein overexpression-mediated multidrug resistance....
Paper Details
Title
Recent advances in research of colchicine binding site inhibitors and their interaction modes with tubulin
Published Date
May 1, 2021
Journal
Volume
13
Issue
9
Pages
839 - 858
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Notes
History