Gene

Statistics

Tree (set theory)

Physics

Data mining

Tree of life (biology)

Engineering

Mathematical analysis

Matching (statistics)

Organic chemistry

Chemistry

Phylogenetic tree

Sensitivity (control systems)

Electronic engineering

Diamond

Scale (ratio)

Mathematics

Computer science

Genetics

Quantum mechanics

Computational biology

Biology

Nature Methods

We are at the beginning of a genomic revolution in which all known species are planned to be sequenced. Accessing such data for comparative analyses is crucial in this new age of data-driven biology. Here, we introduce an improved version of DIAMOND that greatly exceeds previous search performances and harnesses supercomputing to perform tree-of-life scale protein alignments in hours, while matching the sensitivity of the gold standard BLASTP.

Sensitive protein alignments at tree-of-life scale using DIAMOND