Substantial anti-gout effect conferred by common and rare dysfunctional variants of URAT1/SLC22A12
Abstract
Gout, caused by chronic elevation of serum uric acid levels, is the commonest form of inflammatory arthritis. The causative effect of common and rare variants of ATP-binding cassette transporter G2 (ABCG2/BCRP) on gout risk has been studied, but little attention has been paid to the effect of common (rs121907892, p.W258X) and rare variants of urate transporter 1 (URAT1/SLC22A12) on gout, despite dysfunctional variants of URAT1 having been...
Paper Details
Title
Substantial anti-gout effect conferred by common and rare dysfunctional variants of URAT1/SLC22A12
Published Date
Apr 2, 2021
Journal
Volume
60
Issue
11
Pages
5224 - 5232
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