Population-Based Observational Study of Adverse Drug Event-Related Mortality in the Super-Aged Society of Japan

Adverse drug events (ADEs) are a major cause of mortality. We examined long-term trends for ADE-related deaths in Japan. This observational study was conducted using the Japanese Vital Statistics from 1999 to 2016. Data for all ADE-related deaths were extracted using International Classification of Diseases, Tenth Revision codes. We analysed ADE-related deaths by age and sex and calculated crude and age-standardised mortality rates (ASMR) per...