What do we need to know and understand about p53 to improve its clinical value?

Volume: 254, Issue: 4, Pages: 443 - 453
Published: May 6, 2021
Abstract
Few proteins are more studied than the p53 tumour suppressor, but what have we learned from these studies and what do we really know about p53 that can benefit clinical practice? The DNA sequence encoding p53 is frequently mutated in cancers but the functional outcomes of single mutations, in respect to loss or gain of different activities, especially in relation to immune evasion, are not clear. This illustrates p53's complexity which even...
Paper Details
Title
What do we need to know and understand about p53 to improve its clinical value?
Published Date
May 6, 2021
Volume
254
Issue
4
Pages
443 - 453
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.