The in vitro direct mycobacterial growth inhibition assay (MGIA) for the early evaluation of TB vaccine candidates and assessment of protective immunity: a protocol for non-human primate cells

Rachel Tanner; Emily Hoogkamer; Julia Bitencourt; Andrew White; Charelle Boot; Claudia C. Sombroek; Stephanie A. Harris; Matthew K. O'Shea; Daniel B. Wright; Rachel Wittenberg; Helen A. Fletcher; Helen McShane

doi:https://doi.org/10.12688/f1000research.51640.1

doi.org/10.12688/f1000research.51640.1

The in vitro direct mycobacterial growth inhibition assay (MGIA) for the early evaluation of TB vaccine candidates and assessment of protective immunity: a protocol for non-human primate cells

,

..., Helen McShane

Volume: 10, Pages: 257 - 257

Published: Mar 30, 2021

Abstract

The only currently available approach to early efficacy testing of tuberculosis (TB) vaccine candidates isin vivopreclinical challenge models. These typically include mice, guinea pigs and non-human primates (NHPs), which must be exposed to virulentM.tbin a ‘challenge’ experiment following vaccination in order to evaluate protective efficacy. This procedure results in disease development...

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Paper Details

Title

The in vitro direct mycobacterial growth inhibition assay (MGIA) for the early evaluation of TB vaccine candidates and assessment of protective immunity: a protocol for non-human primate cells

DOI

doi.org/10.12688/f1000research.51640.1

Published Date

Mar 30, 2021

Journal

F1000Research

Volume

10

Pages

257 - 257

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