Integrated mutational landscape analysis of uterine leiomyosarcomas
Volume: 118, Issue: 15
Published: Apr 5, 2021
Abstract
Significance Identification of novel, effective treatment modalities for patients with uterine leiomyosarcomas (uLMS) remains an unmet medical need. Using an integrated whole-genome, whole-exome, and RNA-Seq analysis, we identified recurrently mutated genes and deranged pathways, including the homologous-recombination repair (HRR) pathway deficiency (HRD), alternative lengthening of telomere (ALT), C-MYC/BET, and PI3K-AKT-mTOR pathways as...
Paper Details
Title
Integrated mutational landscape analysis of uterine leiomyosarcomas
Published Date
Apr 5, 2021
Volume
118
Issue
15
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