Enhancing CAR-T cell efficacy in solid tumors by targeting the tumor microenvironment

Volume: 18, Issue: 5, Pages: 1085 - 1095
Published: Mar 30, 2021
Abstract
Chimeric antigen receptor (CAR)-T cell therapy has achieved successful outcomes against hematological malignancies and provided a new impetus for treating solid tumors. However, the efficacy of CAR-T cells for solid tumors remains unsatisfactory. The tumor microenvironment has an important role in interfering with and inhibiting the effector function of immune cells, among which upregulated inhibitory checkpoint receptors, soluble suppressive...
Paper Details
Title
Enhancing CAR-T cell efficacy in solid tumors by targeting the tumor microenvironment
Published Date
Mar 30, 2021
Journal
Volume
18
Issue
5
Pages
1085 - 1095
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