METTL3-mediated m6A methylation of SPHK2 promotes gastric cancer progression by targeting KLF2
Abstract
N6-methyladenosine (m6A) RNA methylation is profoundly involved in epigenetic regulation, especially for carcinogenesis and tumor progression. Mounting evidence suggests that methyltransferase METTL3 regulates malignant behaviors of gastric cancer (GC). However, the clinical significance and biological implication of SPHK2 and its related m6A modification in GC remain unclear. In this study, quantitative real-time PCR (qRT-PCR), western blot and...
Paper Details
Title
METTL3-mediated m6A methylation of SPHK2 promotes gastric cancer progression by targeting KLF2
Published Date
Mar 23, 2021
Journal
Volume
40
Issue
16
Pages
2968 - 2981
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