Transcriptional programming drives Ibrutinib-resistance evolution in mantle cell lymphoma
Abstract
Ibrutinib, a bruton's tyrosine kinase (BTK) inhibitor, provokes robust clinical responses in aggressive mantle cell lymphoma (MCL), yet many patients relapse with lethal Ibrutinib-resistant (IR) disease. Here, using genomic, chemical proteomic, and drug screen profiling, we report that enhancer remodeling-mediated transcriptional activation and adaptive signaling changes drive the aggressive phenotypes of IR. Accordingly, IR MCL cells are...
Paper Details
Title
Transcriptional programming drives Ibrutinib-resistance evolution in mantle cell lymphoma
Published Date
Mar 1, 2021
Journal
Volume
34
Issue
11
Pages
108870 - 108870
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