Observation of Collagen-Containing Lesions After Hematoma Resolution in Intracerebral Hemorrhage

Published on Mar 16, 2021in Stroke7.19
· DOI :10.1161/STROKEAHA.120.030240
Christopher J. Love3
Estimated H-index: 3
(MIT: Massachusetts Institute of Technology),
Christopher J. Love (MIT: Massachusetts Institute of Technology)+ 4 AuthorsAdriano Aguzzi111
Estimated H-index: 111
(UZH: University of Zurich)
Background and Purpose: The classic presentation of chronic (stage III) hemorrhagic stroke lesions is a fluid-filled cavity. In one of the most commonly used animal models of intracerebral hemorrha...
#1Teck Chuan Lim (MIT: Massachusetts Institute of Technology)H-Index: 9
#2Emiri T. Mandeville (Harvard University)H-Index: 20
Last. Myron Spector (Brigham and Women's Hospital)H-Index: 67
view all 9 authors...
We assessed an injectable gelatin hydrogel containing epidermal growth factor (Gtn-EGF) as a therapy for intracerebral hemorrhage (ICH). ICH was induced in rats via collagenase injection into the striatum. Two weeks later, Gtn-EGF was injected into the cavitary lesion. The hydrogel filled ICH cavities without deforming brain tissue. Immunostaining demonstrated that neural precursor cells could migrate into the matrix, and some of these differentiated into neurons along with the appearance of ast...
6 CitationsSource
#1Christopher J. Love (MIT: Massachusetts Institute of Technology)H-Index: 3
#2Magdy Selim (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 42
Last. Eng H. Lo (Harvard University)H-Index: 89
view all 4 authors...
2 CitationsSource
#2Minh H. Nguyen ('KCL': King's College London)H-Index: 35
Last. Christopher J L MurrayH-Index: 185
view all 273 authors...
Summary Background Stroke is a leading cause of mortality and disability worldwide and the economic costs of treatment and post-stroke care are substantial. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic, comparable method of quantifying health loss by disease, age, sex, year, and location to provide information to health systems and policy makers on more than 300 causes of disease and injury, including stroke. The results presented here are the estim...
539 CitationsSource
#1Tian Zhou (FSU: Florida State University)H-Index: 1
#2Yiming Zheng (FSU: Florida State University)H-Index: 9
Last. Yi Ren (FSU: Florida State University)H-Index: 32
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The clearance of damaged myelin sheaths is critical to ensure functional recovery from neural injury. Here we show a previously unidentified role for microvessels and their lining endothelial cells in engulfing myelin debris in spinal cord injury (SCI) and experimental autoimmune encephalomyelitis (EAE). We demonstrate that IgG opsonization of myelin debris is required for its effective engulfment by endothelial cells and that the autophagy–lysosome pathway is crucial for degradation of engulfed...
47 CitationsSource
#1Cynthia Soderblom (Miami Project to Cure Paralysis)H-Index: 12
#2Xueting Luo (Miami Project to Cure Paralysis)H-Index: 9
Last. Jae K. Lee (Miami Project to Cure Paralysis)H-Index: 26
view all 11 authors...
Injury to the CNS leads to formation of scar tissue, which is important in sealing the lesion and inhibiting axon regeneration. The fibrotic scar that comprises a dense extracellular matrix is thought to originate from meningeal cells surrounding the CNS. However, using transgenic mice, we demonstrate that perivascular collagen1α1 cells are the main source of the cellular composition of the fibrotic scar after contusive spinal cord injury in which the dura remains intact. Using genetic lineage t...
184 CitationsSource
#1Crystal L. MacLellan (U of A: University of Alberta)H-Index: 19
#2Gergely Silasi (U of A: University of Alberta)H-Index: 18
Last. Frederick Colbourne (U of A: University of Alberta)H-Index: 38
view all 7 authors...
Many therapies have shown promise in preclinical stroke studies, but few benefit patients. A greater understanding of stroke pathophysiology is needed to successfully develop therapies, and this depends on appropriate animal models. The collagenase and blood infusion models of intracerebral hemorrhage (ICH) are widely used; yet, investigators often prefer using one model for a variety of reasons. Thus, we directly compared these to highlight advantages and limitations of each as well as the asse...
289 CitationsSource
Mice display a wound healing process after spinal cord injury that has not been seen in any other species. Rather than exhibiting progressive necrosis and cavitation at the injury site, the mouse lesion site fills in with connective tissue. The connective tissue matrix then undergoes a remodeling in which it contracts, drawing the two ends of the injured spinal cord closer together. One possible explanation for this unique wound healing response is that the spinal cord is much smaller in mice th...
36 CitationsSource
#1Marc R. Del Bigio (UM: University of Manitoba)H-Index: 46
#2Hui-Jin Yan (UM: University of Manitoba)H-Index: 6
Last. James Peeling (UM: University of Manitoba)H-Index: 32
view all 4 authors...
Background and Purpose Intracerebral hemorrhage is associated with a considerable proportion of strokes and head injuries. The mechanism of brain cell injury associated with hemorrhage may be different from that due to pure ischemia. Therefore, it is essential that models of intracerebral hemorrhage be developed and well characterized. The purpose of this study was to obtain high-field MR images of rat brain at progressive times after induction of intracerebral hemorrhage and to correlate the im...
205 CitationsSource
#1Ya-Yen Lee (University of Texas MD Anderson Cancer Center)H-Index: 14
#2Richard P. Moser (University of Texas MD Anderson Cancer Center)H-Index: 14
Last. P. Van Tassel (University of Texas MD Anderson Cancer Center)H-Index: 15
view all 4 authors...
Five cases of pathologically proven organized intracerebral hematoma with recent hemorrhage are reported. The hemorrhages were spontaneous, were located in deep structures of the brain, and presented without a clinical history of hypertension or trauma. No underlying causes of the hematomas were identified histologically. Various computed tomographic (CT) patterns of recurrent hemorrhage in an organized hematoma were observed. A hyperdense, well demarcated mass with minimal contrast enhancement ...
11 CitationsSource
#1S TakasugiH-Index: 1
#2S UedaH-Index: 1
Last. K MatsumotoH-Index: 1
view all 3 authors...
A model of intracerebral hematoma that closely resembles the state in humans after spontaneous intracerebral hematoma was developed. Sequential changes in experimental intracerebral hematomas were compared with the in vivo findings in spontaneous intracerebral hemorrhage. The clinical series consisted of 28 patients with spontaneous intracerebral hemorrhage observed by CT during their natural course from 1976 through 1978. The experimental series consisted of 26 adult mongrel dogs with intracere...
58 CitationsSource
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