Observation of Collagen-Containing Lesions After Hematoma Resolution in Intracerebral Hemorrhage

The classic presentation of chronic (stage III) hemorrhagic stroke lesions is a fluid-filled cavity. In one of the most commonly used animal models of intracerebral hemorrhage (ICH), we noticed additional solid material within the chronic lesion. We examined the composition of those chronic ICH lesions and compared them with human autopsy cases.ICH was induced in rats by the injection of collagenase in the striatum. Tissue sections after...