Low-coverage sequencing cost-effectively detects known and novel variation in underrepresented populations

Volume: 108, Issue: 4, Pages: 656 - 668
Published: Apr 1, 2021
Abstract
Genetic studies in underrepresented populations identify disproportionate numbers of novel associations. However, most genetic studies use genotyping arrays and sequenced reference panels that best capture variation most common in European ancestry populations. To compare data generation strategies best suited for underrepresented populations, we sequenced the whole genomes of 91 individuals to high coverage as part of the Neuropsychiatric...
Paper Details
Title
Low-coverage sequencing cost-effectively detects known and novel variation in underrepresented populations
Published Date
Apr 1, 2021
Volume
108
Issue
4
Pages
656 - 668
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