A novel approach for the detection and identification of sulfur mustard using liquid chromatography–electrospray ionization–tandem mass spectrometry based on its selective oxidation to sulfur mustard monoxide with N ‐iodosuccinimide

A new derivatization strategy for the detection and identification of sulfur mustard (HD) via liquid chromatography–electrospray ionization–tandem mass spectrometry (LC‐ESI‐MS/MS) is developed. The method incorporates selective oxidation of the sulfide group by the electrophilic iodine reagent N ‐iodosuccinimide (NIS) to produce sulfur mustard monoxide (HDSO). The derivatization reaction efficiencies were evaluated with acetonitrile extracts of...