A facile strategy for synthesis of a broad palette of intrinsically radiolabeled chitosan nanoparticles for potential use in cancer theranostics

The conventional, chelator-based techniques used for radiolabelling of nanoparticles possess certain shortcomings due to their inherent limitations related to coordination chemistry. These limitations affect their binding with radioisotopes and alter their pharmacokinetics leading to delayed uptake and clearance from the body and possible detachment of radioisotopes during imaging/treatment. These issues have necessitated the development of...