Glucose-induced insulin secretion in isolated human islets: Does it truly reflect β-cell function in vivo?

Diabetes always involves variable degrees of β-cell demise and malfunction leading to insufficient insulin secretion. Besides clinical investigations, many research projects used rodent islets to study various facets of β-cell pathophysiology. Their important contributions laid the foundations of steadily increasing numbers of experimental studies resorting to isolated human islets.This review, based on an analysis of data published over 60...