Oncolytic virus in gliomas: a review of human clinical investigations

•Oncolytic viruses have shown significant promise in glioma management.•Food and Drug Administration (FDA) approval for oncolytic virus in melanoma has accelerated expansion of the field.•FDA has granted Fast Tract Designation for PVSRIPO and DNX2401 in glioma tumors.•A compendium of completed human trials summarizes the development of the field.•Combining oncolytic therapy with other immunotherapeutics is in the future for the field. Gliomas...