The physiological alteration of histidine-rich glycoprotein on the mice perinatal period.

Histidine-rich glycoprotein (HRG) is an anti-inflammatory factor that controls the progression of systemic inflammatory pathology. In more severe inflammatory condition such as sepsis syndrome, the reduced level of plasma HRG is exacerbating the mortality by inducing to the neutrophil hyperactivity, the promotion of blood coagulation cascade, the vascular endothelial dysfunction, and so on. Although HRG is mainly produced from liver and present...