Synthesis of pH-sensitive nanocarriers based on polyacrylamide grafted nanocrystalline cellulose for targeted drug delivery to folate receptor in breast cancer cells

In this study, nanocrystalline cellulose (NCC) was prepared for the synthesis of new nanocarriers from microcrystalline cellulose to the targeted drug delivery of doxorubicin (DOX) and then a chlorinated derivative of the NCC was prepared as well. The chlorinated NCC was used as a macroinitiator in the atom transfer radical polymerization (ATRP) technique to graft polyacrylamide on NCC chains (PA-g-NCC). Then PA-g-NCC copolymer was further...