Encapsulation of Ellagic Acid in Di-Block Copolymeric Micelle for Non-Small Cell Lung Cancer Therapy

Ellagic acid (EA) is an anticancer agent as evidenced in numerous pre-clinical studies. The clinical application of EA is limited because of its poor aqueous solubility and bioavailability. The present study was designed to formulate polymeric micelles of the drug using poly(L-lactide-co-glycolide)-poly (ethylene glycol) (PLGA-PEG) di-block copolymer. The particle size and entrapment efficiency of EA by the polymeric micelle were found to be...