Anti-ceramide single-chain variable fragment mitigates radiation GI syndrome mortality independent of DNA repair
Abstract
After 9/11, threat of nuclear attack on American urban centers prompted government agencies to develop medical radiation countermeasures to mitigate hematopoietic acute radiation syndrome (H-ARS) and higher-dose gastrointestinal acute radiation syndrome (GI-ARS) lethality. While repurposing leukemia drugs that enhance bone marrow repopulation successfully treats H-ARS in preclinical models, no mitigator potentially deliverable under mass...
Paper Details
Title
Anti-ceramide single-chain variable fragment mitigates radiation GI syndrome mortality independent of DNA repair
Published Date
Apr 22, 2021
Journal
Volume
6
Issue
8
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