Mechanism of misfolding of the human prion protein revealed by a pathological mutation
Volume: 118, Issue: 12
Published: Mar 17, 2021
Abstract
Significance The misfolding and aggregation into amyloid fibrils of the prion protein (PrP) have been strongly linked with a group of neurodegenerative disorders that include the mad cow disease. Currently, the molecular origins of the prion diseases are unknown, including the underlying mechanisms of PrP misfolding and the regions promoting its aggregation. Here, we identified the structural basis by which the folded domain of the human PrP...
Paper Details
Title
Mechanism of misfolding of the human prion protein revealed by a pathological mutation
Published Date
Mar 17, 2021
Volume
118
Issue
12
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