L233P mutation in the bovine leukemia virus Tax protein has impact on annexin A3 and type I collagen secretion by host cells

• Bovine leukemia virus Tax modulated host cell secretion of potential tumor makers. • L233-Tax stimulated annexin A3 secretion. • L233-Tax suppressed type I collagen secretion. • Both L233- and P233-Tax suppressed potentially antiangiogenic molecules secretion. Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leukosis (EBL) and can be classified into two types based on the amino acid at position 233 in Tax protein, which...